A DevOps approach to integration of software components in an EU research project

We present a description of the development and deployment infrastructure being created to support the integration effort of HARNESS, an EU FP7 project. HARNESS is a multi-partner research project intended to bring the power of heterogeneous resources to the cloud. It consists of a number of different services and technologies that interact with the OpenStack cloud computing platform at various levels. Many of these components are being developed independently by different teams at different locations across Europe, and keeping the work fully integrated is a challenge. We use a combination of Vagrant based virtual machines, Docker containers, and Ansible playbooks to provide a consistent and up-to-date environment to each developer. The same playbooks used to configure local virtual machines are also used to manage a static testbed with heterogeneous compute and storage devices, and to automate ephemeral larger-scale deployments to Grid5000. Access to internal projects is managed by GitLab, and automated testing of services within Docker-based environments and integrated deployments within virtual-machines is provided by Buildbot

Enhancing high-level synthesis using a meta-programming approach

In today's increasingly heterogeneous compute landscape, there is high demand for design tools that offer seemingly contradictory features: portable programming abstractions that hide underlying architectural detail, and the capability to optimise and exploit architectural features. Our meta-programming approach, Artisan, decouples application functionality from optimisation concerns to address the complexity of mapping high-level application descriptions onto heterogeneous platforms from which they are abstracted. With Artisan, application experts focus on algorithmic behaviour, while platform and domain experts focus on optimisation and mapping. Artisan offers complete design-flow orchestration in a unified programming environment based on Python 3 to enable accessible codification of reusable optimisation strategies that can be automatically applied to high-level application descriptions. We have developed and evaluated an Artisan prototype and a set of customised meta-programs used to automatically optimise six case study applications for CPU+FPGA targets. In our experiments, Artisan-optimised designs achieve the same order of magnitude speedup as manually optimised designs compared to corresponding unoptimised software

MetaML: automating customizable cross-stage design-flow for deep learning acceleration

This paper introduces a novel optimization frame- work for deep neural network (DNN) hardware accelerators, enabling the rapid development of customized and automated design flows. More specifically, our approach aims to automate the selection and configuration of low-level optimization techniques, encompassing DNN and FPGA low-level optimizations. We introduce novel optimization and transformation tasks for building design-flow architectures, which are highly customizable and flexible, thereby enhancing the performance and efficiency of DNN accelerators. Our results demonstrate considerable reductions of up to 92% in DSP usage and 89% in LUT usage for two networks, while maintaining accuracy and eliminating the need for human effort or domain expertise. In comparison to state-of-the-art approaches, our design achieves higher accuracy and utilizes three times fewer DSP resources, underscoring the advantages of our proposed framework

Perfil clínico-epidemiológico dos pacientes portadores de paracoccidioidomicose no Serviço de Estomatologia do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul Clinical-epidemiologic profile of paracoccidioidomycosis at the Stomatology Department of São Lucas Hospital, Pontificia Universidade Católica of Rio Grande do Sul

No presente estudo, são descritas as características clínicas e epidemiológicas de 61 casos de paracoccidioidomicose, atendidos no Serviço de Estomatologia do Hospital São Lucas da PUCRS, no período de junho de 1976 a junho de 2004. O Rio Grande do Sul é considerado uma região endêmica da doença devido às condições eco-epidemiológicas para o desenvolvimento do fungo. Observou-se que a doença ocorreu em 58 (95%) homens e 3 (5%) mulheres, predominando a faixa etária de 40 a 59 anos (70,5%), e a profissão vinculada à agricultura em 27 (44,3%) pacientes. O hábito de fumar foi prevalente em 52 (85,3%) pacientes da amostra e muitos eram, também, etilistas. Todos os casos apresentavam manifestações estomatológicas, sendo que as lesões orais ocorreram predominantemente com aspecto ulcerado e moriforme, observadas em vários sítios anatômicos. As evidências radiográficas de lesões pulmonares estavam presentes em 32 (65,3%) radiografias avaliadas.<br>The aim of the article was to describe clinical and epidemiological features of 61 oral paracoccidioidomycosis cases from the Stomatology Department of São Lucas Hospital, analyzed from July 1976 to June 2004. The State of Rio Grande do Sul is an endemic region due to ecoepidemiologic conditions, that are favorable for the development of the yeast. Men are the most affected gender, with 58 (95%) affected compared to 3 (5%) women. Ii is most prevalent (70.5%) between 40 and 59 years of age. Agricultural labor was the most common occupation with 27/61 (44.3%) patients. Tobacco smoking was prevalent in 52 (85.3%) of the sample, and alcoholism was a frequent finding. All the patients showed stomatologic manifestations, with ulcers and mulberry-like stomatitis the most prevalent, these oral lesions were also observed in many anatomical sites. Alterations were present in 32 (65.3%) of the pulmonary radiographs

Nutrition in relation to organic aquaculture: Sources and strategies

Organic production is a system of farm management and food production that combines best environmental practices, a high level of biodiversity, the preservation of natural resources, the application of high animal welfare standards and a production method in line with the preference of certain consumers for products produced using natural substances and processes. Mie et al. (2017) reviewed existing evidence on the impact of organic food on human health and compared organic versus conventional food production with respect to parameters important to human health. The review emphasised several documented human health benefits associated with organic food production and production methods and concluded that it is likely to be beneficial within the conventional agriculture, for example, in integrated pest management and antibiotics. This chapter covers aspects of current use of formulated feeds, feed composition, aquafeed technology, sustainable alternatives to common feed ingredients, nutritional physiology and general nutritional principles and product quality in the context of the organic aquaculture. It reviews new knowledge and presents research results to update and may modify the criteria and standards for organic aquaculture in relation to nutrition and thus to provide high-quality products for the consumers. This chapter is based on the current European regulation on organic aquaculture, as well as on the proposed revision of the European regulation, which is currently being approved after a long process for getting the agreement of the European Parliament, European Council and the European Commission

Liraglutide and Renal Outcomes in Type 2 Diabetes.

BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .)